Human homeostatic iron regulator protein, also known as the HFE protein (H igh FE 2+), is a transmembrane protein that in humans is encoded by the HFE gene. The HFE gene is located on …

Linked to the major histocompatibility complex (MHC) on chromosome 6p, HFE encodes the MHC class I-like protein HFE that binds beta-2 microglobulin. HFE influences iron absorption by modulating the …

May 15, 2024 · Hereditary hemochromatosis is most commonly caused by certain changes in a specific gene, called the HFE gene. If you inherit two of these genetic changes (mutations), one from each …

The HFE gene provides instructions for producing a protein that is located on the surface of cells, primarily liver and intestinal cells. Learn about this gene and related health conditions.

Jul 31, 2025 · Explore the HFE genetic mutation, its impact on the body’s essential functions, and how this common inherited variant can influence health.

Hereditary hemochromatosis is a genetic disorder characterized by excessive iron (Fe) accumulation that results in tissue damage. Manifestations can include systemic symptoms, liver disorders, …

Apr 22, 2024 · This topic reviews the genetics and functions of the HFE gene and other genes associated with hereditary hemochromatosis (HH) syndromes, including some of the more …

Jan 9, 2025 · Hemochromatosis (he-moe-kroe-muh-TOE-sis) is a condition that causes the body to absorb too much iron from food. Excess iron is stored in the organs, especially the liver, heart and …

Nov 13, 2025 · HFE (Homeostatic Iron Regulator) is a Protein Coding gene. Diseases associated with HFE include Hemochromatosis, Type 1 and Microvascular Complications Of Diabetes 7.

Dec 6, 2017 · The gene that causes hereditary hemochromatosis, called HFE, was identified on chromosome 6 in 1996. Most cases of HH result from a common mutation in this gene, known as …