SGLT2 inhibitors (gliflozins) were developed as oral antidiabetics. They enhance urinary glucose excretion by inhibiting SGLT-2 (sodium-dependent glucose co-transporter-2) in the renal tubuli. The ...

Researchers uncover a previously unrecognized mechanism that may accelerate polycystic kidney disease. For people with polycystic kidney disease (PKD), life can be a constant cycle of symptoms: aches ...

Inflammation has long been a warning sign in kidney clinics, a red flag that often appears years before a patient tips into ...

Researchers at the University of Tsukuba have developed a novel mouse model that allows them to induce dysfunction in only one kidney. Using this model, they uncovered the molecular mechanisms behind ...

A new study from Aarhus University demonstrates that a protein known for treating cardiovascular diseases also affects a mechanism in the kidney that reabsorbs proteins. This finding could lead to new ...

Niigata, Japan - The gold standard test for predicting the onset of diabetic kidney disease is albuminuria. However, detecting albuminuria alone has limited sensitivity and specificity in end-stage ...

A review article published in the journal Frontiers in Physiology by researchers affiliated with the Federal University of São Paulo (UNIFESP) in Brazil discusses the mechanisms whereby SARS-CoV-2 ...

(Beyond Pesticides, October 1, 2025) A novel study in Scientific Reports combines computational analyses with toxicological data to identify pathways affected by exposure to the weed killer glyphosate ...

University of Texas at Dallas scientists have discovered a previously unknown "housekeeping" process in kidney cells that ejects unwanted content, resulting in cells that rejuvenate themselves and ...

ALTHOUGH many extensive investigations in animals 1–3 have demonstrated the existence of renal medullary hyperosmolality suggestive of a counter-current mechanism of urine concentration, direct ...